The three antibiotics are collectively active against a very wide range of pathogenic organisms. Bacitracin (as the stable zinc salt) is active against many Gram-positive bacteria including Staphylococci, haemolytic and nonhaemolytic Streptococci, Clostridia of the gas gangrene group and certain Gram-negative cocci. Unlike penicillin, bacitracin is not destroyed by Gram-negative bacteria, so can be used in certain mixed infections where penicillin would be inactivated.
Polymyxin B sulfate has a bactericidal action on most Gram-negative organisms, especially Klebsiella aerogenes, K. pneumoniae, Escherichia coli, Shigella sp. and Pseudomonas aeruginosa. Its activity is not affected by the size of the bacterial population and bacterial resistance to it is low.
Neomycin sulfate is a broad spectrum antibiotic effective against many Gram-positive and Gram-negative organisms, including Staphylococcus aureus, Streptococcus pneumoniae, Strep. pyogenes, E. coli and some strains of Proteus vulgaris, Pseudomonas aeruginosa and certain actinomycetes. Neomycin sulfate is not inactivated by bacteria or pus. The product disperses well, is non-irritating and there is good contact of active ingredients with the cornea and aural mucosa.
- Zinc bacitracin 250 U/g
- Neomycin sulfate 5 mg/g
- Polymixin B sulfate 5,000 U/g
Infections due to susceptible organisms.
Meat: 28 days.