Alfaxan®
Injectable Anesthetic

Alfaxan Multidose Packshot

Every day around the globe Alfaxan injectable anesthetic is used in thousands of anesthesia procedures. Its effectiveness, its wider safety profile and its versatility is raising the bar for injectable agents used in induction and total injectable anesthetic procedures.

Drug use and dependence: Alfaxalone is a class IV controlled substance. Biochemical and research data suggest that alfaxalone has a similar abuse and dependence potential to other class IV drugs such as benzodiazepines and barbiturates.


Safety Data Sheet
Alfaxan Safety Data Sheet
Technical Note
Alfaxan Technical Notes

Active Ingredient

Alfaxan Intravenous Injectable Anesthetic for Use in Cats and Dogs (hereafter, Alfaxan) contains the neuroactive steroid molecule alfaxalone (3-α-hydroxy-5-α-pregnane-11, 20-dione) and is registered with the Food and Drug Administration for use in dogs and cats for both the induction and maintenance of anesthesia. Although alfaxalone is a steroid molecule, it does not bind to sex hormone, glucocorticoid or mineralocorticoid receptors (i.e. nuclear receptors. 1,2)

Mode of Action

Alfaxalone produces anesthetic effects via enhancement of gamma-aminobutyric acid sub-type 1 (GABAA) receptor-mediated neurotransmission. GABAA receptors are widely distributed throughout the mammalian Central Nervous System (CNS). GABA is the major inhibitory amino acid transmitter of the mammalian CNS and receptors are present on almost half of all neurones.3 GABA acts by opening a pore in the receptor allowing the in-flow of chloride ions, causing hyperpolarization. Alfaxalone’s enhancement of GABA’s effects prevents development of action potentials and stops impulse transmission.

Alfaxan Overview

Click through to the sections below to find out more on each topic.

Think Anesthesia

Think Anesthesia is Jurox’ proprietary anesthesia education program for veterinarians, veterinary nurses and technicians. For the latest educational content and CE-certified programs.

 

Active Constituents

10 mg/mL Alfaxalone

Indications

Alfaxan is indicated for the induction and maintenance of anesthesia and for induction of anesthesia followed by maintenance with an inhalant anesthetic, in cats and dogs.

Resources

  • Alfaxan FAQs

    Answers to commonly asked questions about Alfaxan

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  • Safety of Alfaxan

    Review Alfaxan's wide safety profile

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  • Alfaxan How to Use

    How to use Alfaxan

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  • What is Alfaxan

    A detailed product overview

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  • Alfaxan use in Sighthounds

    Sighthound Safety Study

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