Safety Information Important Safety Information: As with all drugs, side effects may occur. Zoletil™ for Injection should not be used in dogs and cats with pancreatic disease, renal pathology or impairment of renal function, or severe cardiac or pulmonary dysfunction. Do not use at any stage of pregnancy or for Caesarean section. Do not use phenothiazine derivative drugs concomitantly with Zoletil™ for Injection as the combination produces respiratory and myocardial depression, hypotension, and hypothermia. Pulmonary edema has been reported in cats. Respiratory depression may occur following administration of high doses of Zoletil™. Copious salivation may occur during Zoletil™ anesthesia and may be controlled by giving atropine sulfate, USP as a concurrent medication. Vomiting upon emergence, involuntary muscle twitching and cardiac arrest have occasionally been reported with Zoletil. Refer to the prescribing information for complete details.